Alexandra Levine, M.D.

Dr. Levine's research interests include the lymphomas and Hodgkins disease, as well as the AIDS related malignancies. Multiple studies have been ongoing for years, related to the pathogenisis of disease, as well as well as the optimal therapy for affected patients. Dr. Levine worked on the development and testing of an AIDS vaccine with Dr. Jonas Salk, and has also been on the forefront of the study of HIV disease in women.

Research Interests

• AIDS-Related Cancers
• Hodgkin's Disease
• Lymphoma
• Patient Care

Education

• University of Southern California, Los Angeles, California, M.D., 1971
• University of California, Berkeley, Berkeley, California. B.A., 1966

Selected Publications

Levine AM, Shimodaira S, Lai MMC:  Treatment of HCV related mantle cell lymphoma with ribavirin and pegylated interferon alfa.  N Engl J Med 349:2078-79, 2003.

Hessol NA, Seaberg EC, Preston-Martin S, Massad LS, Sacks HS, Silver S, Melnick S, Abulafia D, Levine AM: Cancer risk among participants in the Women’s Interagency HIV Study (WIHS).  JAIDS 36:978-985, 2004.

Berhane K, Karim R, Cohen MH, Masri-Lavine L, Young M, Anastos K, Augenbraun M, Watts DH, Levine AM:  Impact of highly active anti-retroviral therapy on anemia, and relationship between anemia and survival in a large cohort of HIV infected women:  Women’s Interagency HIV Study.  JAIDS 37:1245-1252, 2004.
 
Arzoo KK, Bu X, Espina BM, Seneviratne L, Nathwani B, Levine AM:  T cell lymphoma in HIV infected patients. JAIDS 36:1020-1027, 2004.
 
Levine AM, Tulpule A, Espina B, Sherrod A, Boswell WD, Lieberman RD, Nathwani BN, Welles L: Liposome encapsulated doxorubicin (Myocet) in combination with standard agents (cyclophosphamide, vincristine, prednisone) in patients with newly diagnosed AIDS related non-Hodgkin’s lymphoma:  Results of therapy and correlates of response.  J Clin Oncol 22:2662-2670, 2004.
 
Lim ST, Tupule A, Espina BM, Levine AM: Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma. Cancer 103:417-21, 2005.
 
Lim ST, Rubin N, Said J, Levine AM: Primary Effusion Lymphoma (PEL): Successful treatment with highly active antiretroviral therapy (HAART) and Rituximab. Ann Hematol 84:551-552, 2005.
 
Lim ST, Levine AM: Angiogenesis and Hematological Malignancies. Hematology 10:11-24, 2005
 
Richardson JL, Mowicki M, Danley K, Martin EM, Cohen MH, Gonzalez R, Vassileva J, Levine AM:  Neuropsychological functioning in a cohort of HIV and HCV infected women. AIDS 2005; 19(15):1659-1667.
 
Lim ST, Karim R, Nathwani BN, Tulpule A, Espina B, Levine AM:  AIDS-Related Burkitt’s Lymphoma (HIV-BL) versus Diffuse Large cell Lymphoma (HIV-DLCL) in the Pre-HAART and HAART Eras: Significant Differences in Survival with Standard Chemotherapy. JCO 23:4430-4438, 2005.
 
Lim ST, Karim R, Tulpule A, Nathwani BN, Levine AM: Prognostic factors in HIV related diffuse large cell lymphoma:  Before versus after highly active antiretroviral therapy.  J Clin Oncol 2005; 23: 8477-8482.
 
Levine AM, Karim R, Mack W, Gravink DJ, Anastos K, Young M, Cohen M, Newman M, Augenbraun M, Gange S, Watts DH:  Neutropenia in HIV infection:  Data from the Women’s Interagency HIV Study.  Archives Internal Medicine, 2006; 166:405-410.
 
Levine AM, Tulpule A, Quinn DI, Gorospe G, Smith DL, Hornor L, Espina BM, Groshen SG, Masood R, Gill PS:  Phase I study of anti-sense oligonucleotide against vascular endothelial growth factor (VEGF-AS):  Decrease in plasma VEGF with potential clinical efficacy.  J Clin Oncol 2006; 24: 1712-1719.

Shaye OS and Levine AM:  Marginal Zone Lymphoma. Jour NCCN 2006; 4:311-318.
 
Tulpule A, Espina BM, Berman N, Buchanan LH, Smith DL, Sherrod A, Dharmapala D, Gee C, Boswell WD, Nathwani BN, Welles L, Levine AM: Phase I/II trial of non-pegylated liposomal doxorubicin (TLC-D99; MyocetTM), cyclophosphamide, vincristine, and prednisone in the treatment of newly diagnosed aggressive non-Hodgkin's lymphoma.  Clin Lymphoma and Myeloma 2006; 7:59-64.
 
Levine AM, Vigen C, Gravink J, Mack W, Watts CH, Liebman HA:  Progressive prothrombotic state in women with advancing HIV disease.  JAIDS 2006; 42:572-7.
 
Levine AM: Monoclonal gammopathy associated with HIV infection: Commentary.  Clin Infect Disease 2006; 43:1206-8.
 
Levine AM: Hodgkin lymphoma:  To the HAART of the Matter (Editorial).  Blood 2006; 108:3630-31.
 
Khalsa A, Karim R, Mack WJ, Minkoff H, Cohen M, Young M, Anastos K, Tien PC, Seaberg E, Levine AM:  Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women’s Interagency HIV Study (WIHS).  AIDS 2007; 21:2539-41.
 
Nowicki MJ, Vigen C, Mack WJ, Seaberg E, Landay AL, Greenblatt R, Anastos K, Cohen M, Minkoff H, Levine AM: Association of cells with natural killer and NKT immunophenotype with incident cancers in HIV infected women.  AIDS Res and Human Retroviruses 2008; 24:163-8.